Project Description

Cox proportional hazard model: zMS* and each of its component – associated with incident type 2 diabetes (*Standardized multivariate score). Stepwise proportional hazards models: fasting glucose, 2-h glucose, HDL cholesterol, and BMI – independent diabetes predictors; and were weaker predictors than zMS. Parsimonious summary score: combined variables had predictive power similar to that of zMS. Intrauterine diabetes exposure or parental history of young-onset diabetes increased a child’s absolute risk of developing diabetes.
Strategies targeting obesity, dysregulated glucose homeostasis, and low HD cholesterol during childhood and adolescence would bring the most success in preventing diabetes.
After the initial diagnosis of Diabetes Type 2 or its risk factors, life style modification can reverse the disease.